The locus coeruleus and central chemosensitivity
نویسندگان
چکیده
منابع مشابه
Theoretical perspectives on central chemosensitivity: CO2/H+-sensitive neurons in the locus coeruleus
Central chemoreceptors are highly sensitive neurons that respond to changes in pH and CO2 levels. An increase in CO2/H+ typically reflects a rise in the firing rate of these neurons, which stimulates an increase in ventilation. Here, we present an ionic current model that reproduces the basic electrophysiological activity of individual CO2/H+-sensitive neurons from the locus coeruleus (LC). We ...
متن کاملInvolvement of TRP channels in the CO2 chemosensitivity of locus coeruleus neurons
Cui N, Zhang X, Tadepalli JS, Yu L, Gai H, Petit J, Pamulapati RT, Jin X, Jiang C. Involvement of TRP channels in the CO2 chemosensitivity of locus coeruleus neurons. J Neurophysiol 105: 2791–2801, 2011. First published March 23, 2011; doi:10.1152/jn.00759.2010.—Catecholaminergic neurons in the locus coeruleus (LC) play a role in the ventilatory response to hypercapnia. Here, we show evidence f...
متن کاملInvolvement of TRP channels in the CO 2 chemosensitivity of locus coeruleus neurons 3 4
4 Ningren Cui*, Xiaoli Zhang*, Jyothirmayee S. Tadepalli, Lei Yu, Hongyu Gai, James Petit, 5 Ravi T. Pamulapati, Xin Jin and Chun Jiang 6 7 Department of Biology, Georgia State University, 100 Piedmont Avenue, Suite 495 8 P.O. Box 4010, Atlanta, GA 30302 9 10 11 12 13 Running head: TRP channels in neuronal CO2 chemosensitivity 14 15 Number of text pages: 28 16 17 Number of display items: 10 18 ...
متن کاملInvolvement of TRP channels in the CO₂ chemosensitivity of locus coeruleus neurons.
Catecholaminergic neurons in the locus coeruleus (LC) play a role in the ventilatory response to hypercapnia. Here, we show evidence for the involvement of transient receptor potential (TRP) channels. We found that the input resistance was reduced during an exposure to 8% CO(2) in ~35% LC neurons in mouse brain slices, accompanied by depolarization and higher firing activity. The neuronal respo...
متن کاملLocus coeruleus is a central chemoreceptive site in toads.
The locus coeruleus (LC) has been suggested as a CO2 chemoreceptor site in mammals. This nucleus is a mesencephalic structure of the amphibian brain and is probably homologous to the LC in mammals. There are no data available for the role of LC in the central chemoreception of amphibians. Thus the present study was designed to investigate whether LC of toads (Bufo schneideri) is a CO2/H+ chemor...
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ژورنال
عنوان ژورنال: Respiratory Physiology & Neurobiology
سال: 2010
ISSN: 1569-9048
DOI: 10.1016/j.resp.2010.04.024